Since over 92% of prophylactic gastrectomies in CDH1 mutated patients with family history of HDGC will reveal SRCC on pathologic examination, a recent study suggested presenting the total gastrectomy procedure to patients as a curative, rather than a prophylactic option [11, 12]. The gene discussed is CDH1; the disease is CDH1-related diffuse gastric and lobular breast cancer syndrome.