Considering the different hormone receptor status, dose-dense chemotherapy conferred a significant improvement in DFS in patients with hormone receptor-negative tumor (HR = 0.74; 95%CI 0.62–0.89; p = 0.001; I2 = 0%), while patients with hormone receptor-positive tumor obtained no significant DFS benefit (p = 0.53) (interaction test, p = 0.20). The gene discussed is NR4A1; the disease is neoplasm.