More than NNT‐AS1, other lncRNAs also modulate the cellular process of GC cells.28 For example, lncRNA SNHG6 is overexpressed in gastric cancer tissues and cell lines, and SNHG6 could epigenetically silence p27 and competitively sponge miR‐101‐3p to regulate ZEB1.29 In HCC tumorigenesis, NNT‐AS1 knockdown inhibited the HCC cells progression via miR‐363 thereby targeting CDK6 expression.18 Therefore, our study firstly confirmed the oncogenic role of lincRNA NNT‐AS1 in GC tumorigenesis, revealing the vital pathway of NNT‐AS1/miR‐424/E2F1 axis. This evidence concerns the gene CDK6 and gastric cancer.