In addition, pegfilgrastim (G-CSF) was applied: to examine the effect of pegfilgrastim on neutropenia and the time of hospitalization, the study compared cycles 2 and 4 where pegfilgrastim was given routinely from day 6 (IDAC-P) with cycle 3 where pegfilgrastim was only administered in case of severe infections and/or prolonged neutropenia. Here, CSF3 is linked to neutropenia.