APOE and Alzheimer disease: By the conventional approach of genome-wide association study (Hirano et al. 2015) (811 AD case individuals and 7504 control individuals with 583,884 SNPs on autosomes), we observed six significant SNPs with genome-wide significance (p < 5.0 × 10−8) on 19q13 including the APOE gene (Supplementary Fig. 1a), a well-known risk factor of AD (Saunders and Roses 1993; Saunders et al. 1993a, b), and several adjacent genes.