For KLK8 (kallikrein-related peptidase 8), it was previously shown that its mRNA levels in AD hippocampus were significantly higher than in controls (Shimizu-Okabe et al. 2001), and its protease was recently reported as a suggestive factor for increasing the risk for AD specifically in females (Keyvani et al. 2018). Here, KLK8 is linked to Alzheimer disease.