BRCA1 and neoplasm: As expected, we found SUM149 cells to display one of the most profound PARP inhibitor sensitivity effects in the panel of 92 tumour cell lines (ranked 3rd, 2nd, and 5th for olaparib, talazoparib and rucaparib sensitivity respectively, Fig. 2E–G), whereas the SUM149 BRCA1 revertant tumour clone displayed profound PARPi resistance (Fig. 2E–G).