We also found that OS tumour cell lines with FGFR1 amplification (G292, NOS1 and CAL72) or FGFR1 gain (HU09 and NY) were significantly more sensitive to both AZ547 and PD173074 than those OS tumour cell lines without FGFR1 copy number alterations (Fig. 1H,I, p < 0.01 in both cases, Mann-Whitney uncorrected test and Fig. 1J,K). This evidence concerns the gene NOS1 and neoplasm.