RB1 and cancer: Similarly, we noticed that, as for other cancer histotypes12, RB1 (Retinoblastoma) tumour suppressor defects in OS TCLs (Supplementary Table 711 were associated with resistance to the CDK4,6 inhibitor, palbociclib (Fig. 1L, p 0.031, Mann-Whitney uncorrected test), suggesting that genotype-specific drug sensitivity effects in OS TCLs could be identified.