S1PR3 and neoplasm: When injected into mice, S1P3 overexpressing tumor cells produced 59% greater micrometastases (231-BR-Vector median = 350, IQR = 258–458; 231-BR-S1P3 median = 557, IQR = 378–611; P = 0.0374, Two-tailed Mann–Whitney statistical test) and 44% greater large metastases (the latter was not significant: 231-BR-Vector median = 6.9, IQR = 4.15–8.3; 231-BR-S1P3 median = 12.33, IQR = 5.2–13.4; P = ns) (Fig. 9c, d).