GHR and cholangiocarcinoma: These gains include genes on 5p known to be involved in the JAK-STAT signaling pathway and the development of metastases25, Growth Hormone Receptor (GHR), which was overexpressed in metastatic breast cancer26 and Leukemia Inhibitory Factor Receptor Alpha (LIFR), which was involved in chemoresistance of cholangiocarcinoma cells27.