GLP1R and obesity due to melanocortin 4 receptor deficiency: In addition, the data in this study suggest the possibility that incretin-related drugs such as GLP-1 receptor agonist would exert more protective effects on arteries in non-obese subjects and that amelioration of obesity would be beneficial to augment the protective effects of such drugs on arteries although further evaluation such as prospective clinical study would be necessary to demonstrate these points.