Since obese-prediabetic (4-HCD) mice had elevated insulin (Table S1) and normalized adiponectin levels (Fig. 1f), and PIV responses had become similar to age-matched lean mice (Fig. 3a), we explored the possibility that hyperinsulinemia-driven insulin signalling was involved in the adaptive mechanism to normalize PIV. Here, ADIPOQ is linked to Hyperinsulinemia.