In addition, the p.G607G mutation at the Lmna locus or the p.T279A mutation at the Dmd locus create clinical signs and symptoms associated with classical HGPS mutation (p.G608G) or XLCM mutation (p.T279A) in humans (Figs. 4a, 5a). Here, DMD is linked to Hutchinson-Gilford progeria syndrome.