In addition, the p.G607G mutation at the Lmna locus or the p.T279A mutation at the Dmd locus create clinical signs and symptoms associated with classical HGPS mutation (p.G608G) or XLCM mutation (p.T279A) in humans (Figs. 4a, 5a). The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.