Specifically, we focused on CD58 among those those genes because of association of CD58 with NK cell cytotoxicity based on previous reports21,22, demonstrated that CD58 was increased in anisomycin-treated HepG2, SNU449, and Huh7 cells and performed its role to boost susceptibility to NK cell cytotoxicity in the three different HCC cells (Fig. 4c,d). This evidence concerns the gene CD58 and hepatocellular carcinoma.