Among these genes, we aimed to identify genes whose alterations might affect NK cell cytotoxicity in HCC cells and found that CD58, ICAM4, Interferon-induced protein (IFIT)1, IFIT2, IFIT3 and KIT ligand (KITLG) were significantly up-regulated and CD46, ECM1, EMP2, and ITGB2 were down-regulated in anisomycin-treated HepG2 cells via a comparative analysis of previously reported data (Fig. 4b). Here, ICAM4 is linked to hepatocellular carcinoma.