While we could not clearly understand what make differences in the apoptotic effect upon co-culture effect with NK cells on different HCC cells yet, it might be possible that a combined effects of multiple molecules such as CD58, ICAM-4, MHC-I (HLA-A,B,C) which were differentially regulated by anisomycin in different cells could make HepG2 cells to be more sensitive for NK cell cytotoxicity in comparison to SNU449 and Huh7. The gene discussed is CD58; the disease is hepatocellular carcinoma.