ICAM4 and hepatocellular carcinoma: While we could not clearly understand what make differences in the apoptotic effect upon co-culture effect with NK cells on different HCC cells yet, it might be possible that a combined effects of multiple molecules such as CD58, ICAM-4, MHC-I (HLA-A,B,C) which were differentially regulated by anisomycin in different cells could make HepG2 cells to be more sensitive for NK cell cytotoxicity in comparison to SNU449 and Huh7.