The DP CD8 TILs specifically recognized autologous tumor cells in an major histocompatibility complex (MHC)-class I-dependent manner, as little to no reactivity was observed following Major Histocompatibility Complex (MHC)-class I blockade or when T cells were co-cultured with an allogeneic tumor cell line (Fig. 6b and Supplementary Fig. 7b). Here, CD8A is linked to neoplasm.