PF4 and myocardial infarction: Since experimental inhibition of CCL5 showed cardioprotective effects during myocardial reperfusion12,25,26 and the formation of NETs is also associated with its pathophysiology27, we hypothesize that blocking CCL5-CXCL4 interactions will have therapeutic benefits in the early phase of MI, with potential impact on injury progression and healing after I/R injury.