TGFB1 and posterior cortical atrophy: As shown in Fig. 3c and Supplementary Figure 4a, upregulating miR-133b significantly repressed, while silencing miR-133b enhanced the transcriptional activity of the TGF-β/Smad-responsive luciferase reporter in the absence or presence of ectopic TGF-β in PCa cells, and the expression levels of miR-133b in PCa cells was not affected by TGF-β treatment (Supplementary Figure 4b).