UTY and neoplasm: Nonetheless, our results, combined with the finding that UTY is rarely mutated or deleted in cancer (http://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=kdm6b), suggest that deficiency of the only copy of UTX in males is expected to sufficiently allow for tumorigenesis, and the presence of UTY on Y chromosome would not significantly impede tumor formation caused by UTX loss.