ASM cells from COPD patients were stimulated with either 10% FBS (Figure 2A), 10 ng/ml PDGF (Figure 2B), or 10 ng/ml EGF (Figure 2C) for 72 h and pre-treated with either DMSO, or TC ASK 10 at increasing concentrations of 10 nM, 100 nM and 1 μM. Here, EGF is linked to chronic obstructive pulmonary disease.