As theta oscillations are suggested to be important in cognitive functioning (Basar et al., 2001; Jones and Wilson, 2005), the effects on theta power in these data may explain the suggested cognitive deficits observed in some studies with mGluR2/3 agonists in normal animals (Higgins et al., 2004; Schlumberger et al., 2009). The gene discussed is GRM2; the disease is Cognitive impairment.