Further, FGF2 knockout in the carbon tetrachloride mouse model of hepatic injury was associated with decreased collagen expression and protection from liver fibrosis [37], while Brivanib, an inhibitor of FGFR and vascular endothelial growth factor (VEGF) was shown to inhibit activation of hepatic stellate cells in vitro and liver fibrosis in three different animal models [38]. This evidence concerns the gene VEGFA and Hepatic fibrosis.