RAC1 and Alzheimer disease: Rac1 levels significantly increased in the plasma of the AD patients with MMSE< 18 compared to controls (p = 0.0002), MCI (p = 0.045), and the AD group with MMSE≥18 (p = 0.0051) (Kruskal-Wallis followed by Dunn’s multiple comparison test) (Fig. 1b).