In support, studies have demonstrated that CD44+ cancer stem-like cells obtained from different cancer types, are found to be resistant against drug treatment and with increased expression of powerful oncogenes such as c-Myc and Wnt/β-catenin [10–12] and ones identified in this study, NF-κB, Notch1 and decreased pro-apoptotic marker Bax [13, 14]. Here, NOTCH1 is linked to cancer.