Interestingly, SORL1 also showed differences in gene expression after liprin-α1 knockdown in breast cancer and in HNSCC cell lines (Fig. 3a, Additional file 6: Figure S3A, Additional file 2: Table S1) (SORL1; MDA-MB-231, p = 1.7^-15, (log2) fold change = 1.8, and HNSCC, p = 0.0099, (log2) fold change = 1.1). This evidence concerns the gene SORL1 and head and neck squamous cell carcinoma.