Our prediction models for liver fat on the continuous scale revealed a model R2 of 53.9% when using our own set of predictors (waist, ALT, GGT, HbA1c, insulin, and creatinine) vs. 41.4% when using the predictors selected by Kotronen et al. (AST, AST/ALT ratio, diabetes type 2, metabolic syndrome, and insulin) [9]. The gene discussed is INS; the disease is type 2 diabetes mellitus.