NPHP4 and retinitis: Similarly, other wolf-excess genes were related to cardiac (KCNAB2, WDPCP), pancreatic (PLCG2), bone and retinal (NPHP4) disorders that have been widely described in a number of dog breeds [64], but not yet in wolves, and that could provide a higher resistance of CWDs to such disorders compared to German Shepherds.