NFKB1 and colonic neoplasm: In contrast, while a previous finding demonstrated suppression of NF-κB via AMPK activation by curcumin in human colon cancer cells [42], our data indicate that in curcumin-stimulated A549 cells, the transcriptional activation of the hST8Sia I gene is induced by the activation of NF-κB via the AMPK signaling pathway.