SLC6A14 and cystic fibrosis: As shown in Figure 2, disruption of Slc6a14 in CF mice (Cftr(F508del/F508del)Slc6a14(-/y)) led to a further reduction in weight gain and BMI post weaning (day 34), relative to age matched controls, (Cftr(F508del/F508del)Slc6a14(+/y)) (Figure 2a,b,c, Figure 2—figure supplement 1).