SLC6A14 has been identified as a genetic modifier of multiple CF disease outcomes, including meconium ileus (Sun et al., 2012), lung disease (Corvol et al., 2015) and the age of first infection by Pseudomonas aeruginosa (Li et al., 2014). The gene discussed is SLC6A14; the disease is intestinal obstruction in the newborn due to guanylate cyclase 2C deficiency.