IL‐37 has been identified as a natural suppressor of innate inflammatory and immune responses.8, 12 Recent studies have indicated that IL‐37 plays a protective role in tumor progression in mouse fibrosarcoma,9 human lung cancer,14, 42 hepatocellular carcinoma,13 breast cancer,43 cervical cancer,44 and renal cell carcinoma.45 Zhang et al15 found that IL‐37 inhibits colon cancer progression via β‐catenin suppression and that a lack of IL‐37 is associated with poor survival. This evidence concerns the gene IL37 and renal cell carcinoma.