IL‐37 contributes to the immunosuppressive property of human regulatory T cells, and its antitumor activity was identified by the recruitment of more natural killer cells in hepatocellular carcinoma.11, 13 In addition, we found that low IL‐37 expression and dMMR status are associated with high CD66b+ TAN levels in CRC. Here, CEACAM8 is linked to colorectal carcinoma.