Previous study also showed that IL‐37 mediated anti‐tumor immune responses through recruiting NK cells to tumor microenvironment in hepatocellular carcinoma.13 However, Ge et al14 found no change in TILs frequencies in tumors over‐expressing IL‐37, suggesting that IL‐37 might not affect the anti‐tumor immune responses in vivo. This evidence concerns the gene IL37 and neoplasm.