Improved prediction of individual prognosis could be useful for counseling patients, personalizing treatment, and scheduling patient follow‐ups.3, 4 Although several CRC nomograms are available, no particular nomogram has been widely clinically used.3, 4 In the study, we constructed and validated the two nomograms integrating the IL‐37 expression determined by IHC, CD66b+ TAN level, MMR status, T stage, N stage, M stage, and CEA level to improve the accuracy of prediction. This evidence concerns the gene CEACAM8 and colorectal carcinoma.