CXCL8 and colorectal carcinoma: CXCL8 mRNA and protein levels have been found to be significantly upregulated upon IL‐37 downregulation in colon epithelial cells, and CXCL8 can selectively recruit neutrophils.10 This suggests that IL‐37 might inhibit the recruitment of neutrophils, which is in consistent with our results that low IL‐37 expression was associated with a high CD66b+ TAN level in CRC.