Amongst these correlated events, the relationship to hnRNP H insolubility varied; for example, splicing changes at hnRNPA3 followed a linear relationship similar to BBS, GABRG2 and CCDC136; in turn, splicing changes at hnRNPH1 occurred only when hnRNP H insolubility was above 60%, primarily in FTD patients and some C9 patients. The gene discussed is CCDC136; the disease is frontotemporal dementia.