For example, disease-linked changes affecting the solubility properties of other RBPs (Harrison and Shorter, 2017), including hnRNP H (Conlon et al., 2016), have the potential to affect solubility of RBPs they interact with, like TDP-43 (Freibaum et al., 2010; Ling et al., 2010), although whether this occurs in ALS/FTD patient brains is unknown. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.