KCNMA1 and Sepsis: 2011; Liu et al. 2017). Previous studies documented that DMY has oxidation resistance, anti-inflammatory, free radical scavenging capabilities among other biological activities (Zhang et al. 2003). The effects of DMY on LPS-induced vascular hyporesponsivity to vasopressor agents, has not been reported. This study explores the effects of DMY on vascular hyporesponsivity in an experimental sepsis model by focusing special attention on the role of VSMCs MaxiK and KATP channels in freshly isolated rat thoracic aorta.