This could have particular relevance in cardiac ageing, where MAO‐A is likely to be chronically activated due to: (a) sympathetic activation and enhanced release of norepinephrine from adrenergic nerves (Santulli & Iaccarino, 2016); and (b) overexpression of MAO‐A in the ageing heart (as shown in Figure 1a,b) or in age‐associated cardiac diseases (Manni et al., 2016; Villeneuve et al., 2013). This evidence concerns the gene MAOA and heart disorder.