Metformin is also reported to have a direct effect on CD8+ T cells for protection against the inevitable functional exhaustion marker T‐cell immunoglobulin and mucin domain‐containing protein‐3 (Tim‐3) in the tumor microenvironment.77 The production of secreted suppressive molecules such as IL‐6 leads to the limited efficacy of immune checkpoint inhibitors in PDAC, so IL‐6 blockade would modulate the immunological features of PDAC. This evidence concerns the gene CD8A and neoplasm.