NLR kinetics in patients with advanced solid tumors treated with PD‐1/PD‐L1 inhibitors showed that the median OS for patients with a high NLR was 8.5 months, compared to 19.4 for patients with low NLR (P = .01).88 The importance of NLR was also reported in a study of a peptide vaccine against CRC.17 Circulating CD8+ T cells are incontrovertibly important. The gene discussed is PDCD1; the disease is colorectal carcinoma.