Depleting FAP+ carcinoma‐associated fibroblasts in mouse models was shown to be synergistic with vaccine‐based or immune checkpoint‐based immunotherapies in eliciting anti‐tumor immunity and tumor regression.49, 50 However, therapeutically targeting the stroma of pancreatic cancer is challenging in humans as the cells that comprise this tissue compartment are present throughout the human body and play important roles in normal homeostasis. The gene discussed is FAP; the disease is familial pancreatic carcinoma.