In fact, high PD-L1 expression was associated with a better prognosis than low PD-L1 expression in several cancer types, including gastric cancer [21], colorectal cancer [22, 23], breast cancer [24, 25], metastatic melanoma [26], Merkel cell carcinoma [27], glioblastoma [28], and other cancer [29–31]. Here, CD274 is linked to metastatic melanoma.