In conclusion, our preliminary study showed two interesting and totally unexpected facts: (1) young diabetic IRS2-KO mice are protected against glycogen accumulation in renal tubules despite hyperglycemia and (2) NaW treatment normalized glycemia in IRS2-KO mice but induced glycogen accumulation in the kidney, specifically in proximal tubules from the cortex. Here, IRS2 is linked to Hyperglycemia.