KEGG pathway analysis also showed that hypomethylated genes were mainly involved the following pathways: (1) Rap1 signaling pathway, (2) focal adhesion, (3) pathways in cancer, (4) phosphatidylinositol signaling system, (5) adherens junction, (6) axon guidance, (7) retrograde endocannabinoid signaling, (8) cholinergic synapse, (9) insulin secretion, and (10) glutamatergic synapse (Figure 3(d)). This evidence concerns the gene INS and cancer.