C3 and IgA glomerulonephritis: A previous study examined the effect of the deposition of C3a and C5a in 83 patients with renal biopsy proven IgA nephropathy [6] and concluded that the deposition increased with increasing grades of renal pathology in IgAN patients, while it correlated with proteinuria and serum creatinine (SCr), which is in agreement with our findings.