PLOD2 is induced by hypoxia-inducible factor-1α (HIF-1α) under hypoxia condition, which in turn enhance hypoxia-induced Epithelial-Mesenchymal Transition (EMT) phenotypes in glioma cells (Song et al., 2017) and breast cancer cells (Gilkes et al., 2013b). This evidence concerns the gene PLOD2 and central nervous system cancer.