P2RX7 and cancer: Given the recent progress in our understanding of the importance of autophagy-dependent processes in physiology and a range of human pathologies as diverse as neurological /neurodegenerative diseases (Alzheimer's, dementia, Parkinson's, and MLS), muscular dystrophies, infectious, lysosomal storage diseases, Crohn's, cancers and aging (Young et al., 2009, 2015; Rubinsztein et al., 2011; Nikoletopoulou et al., 2015; Qian et al., 2017), this link may suggest a potential for tuning autophagic responses in diverse human pathologies using P2RX7 modulation.