P2RX7 and depressive symptom measurement: Despite these limitations, >70 patents for P2RX7 antagonists have been filed in the last few years, including for the use of A438079 in depression, anxiety and bipolar disorders, triazole-based drugs for CNS disorders and P2RX7 antagonists in epithelial cancers (from GSK, Abbott and Cleveland University Hospitals, respectively (Park and Kim, 2016).