Few previous studies demonstrated that dietary fat induced osteoarthritis.14,15 In addition, a recent study demonstrated that palmitate, but not oleate, has a pro-apoptotic effect on interleukin 1 beta (IL-1-β)-stimulated articular chondrocytes.16 However, the molecular mechanism by which FFAs exert lipotoxicity remains largely unknown. The gene discussed is IL1B; the disease is osteoarthritis.