The serial changes of C1-INH activity values were evaluated in 40 patients with sepsis (30 men and 10 women; 30 survivors and 10 non-survivors; mean age, 70.0 ± 13.5 years): the non-shock group (n = 14), the non-refractory shock group (n = 13), and the refractory shock group (n = 13: 3 survivors, 10 non-survivors). This evidence concerns the gene SERPING1 and Sepsis.