In particular, novel promising NASH and NAFLD drugs (GLP-1R antagonists, pioglitazone, vitamin E, elafibranor, OCA, selonsertib, simtuzumab, GR-MD-02, and CVC) from the pipeline of the pharmaceutical industry are being tested in advanced clinical trials and possibly will be approved as medications in the near future. The gene discussed is GLP1R; the disease is metabolic dysfunction-associated steatohepatitis.