Expression of tissue inhibitor of metalloproteinase 3 (TIMP3) was repressed by LSD1-mediated H3K4me2 demethylation at TIMP3 promoter, which consequently enhanced MMP2 expression as well as JNK phosphorylation, and eventually promoted the metastasis of NSCLC cells [101]. Here, KDM1A is linked to non-small cell lung carcinoma.