Interestingly, during the process of TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in lung cancer, H3K79me3 was decreased without association with DOT1L expression; and DOT1L inhibitors, EPZ5676 and SGC0946, were not effective on EMT-related genes [85]. This evidence concerns the gene DOT1L and lung carcinoma.