The link between lung cancer and KDM6A, a H3K27-specific demethylase which usually acts antagonistically to EZH2, was previously studied in NSCLC cells with controversial outcomes: KDM6A epigenetically antagonized TGF-β-induced EMT process [121]; whereas its inhibitor GSKJ4 demonstrated anticancer-effect on a set of NSCLC cell lines [122]. This evidence concerns the gene TGFB1 and lung cancer.