Additionally, KDM3A knockdown decreased the expression of tumor-promoting EZH2 and increased the anti-tumor miRNA let-7c expression, thus inhibited tumorigenesis in NSCLC cell lines and xenograft model [109].Recently, KDM3A was also found to facilitate the immune evasion of A549 cells by promoting Foxp3 transcription [110], which provides another evidence that KDM3A acts as an oncogene in lung cancer. This evidence concerns the gene EZH2 and neoplasm.