Therefore, the aim of the present study was to determine the frequency of infiltrating CD4+ and CD8+ T cells and macrophages (CD68+ cells), additionally the mRNA expression of Th cell subsets (T-bet, GATA3, Ror-γt, and FoxP3) in the sinonasal mucosa of CRSwNP and CRSsNP patients in comparison to healthy controls. The gene discussed is CD8A; the disease is chronic rhinosinusitis without nasal polyps.