Expression of fly lamin C with mutations representing human lamin A laminopathy mutations such as N210K (N195K in human lamin A/C), R401K (R386K), K493W (K453W), W557S (W520S) and L567P (L530P) under the control of different drivers were lethal except when drivers provided a low level of mutant protein comparable to endogenous lamin C [55, 79]. This evidence concerns the gene LMNA and laminopathy.