Our previous reports also have established that a number of matrix metalloproteinases (MMPs), known to be upregulated in cancers, including OSCC, bind and interact with specific MMPs in biochemical and biologic systems: MMP2 with BSP; MMP3 with OPN; MMP9 with DMP1; and MMP20 with DSPP [17, 18, 21–23]. This evidence concerns the gene DSPP and cancer.