The anti-PD-L1 antibodies (PD-L1ab) atezolizumab (urothelial carcinoma and NSCLC), durvalumab (urothelial carcinoma), and avelumab [Merkel-cell carcinoma (MCC) and urothelial carcinoma] have also recently been approved by the FDA (13–18). This evidence concerns the gene CD274 and Merkel cell skin cancer.