Functional RIG-I can be activated against some kinds of tumors, to evaluate whether there is functional RIG-I in NPC cell lines, different human nasopharyngeal epithelial cell lines were cultured in the absence or presence of 100 IU/ml IFN-α for 12 h, expression of RIG-I was determined by Western blot analysis. Here, IFNA1 is linked to nasopharyngeal carcinoma.