In this study, we found that LMP1 downregulated the Sendai virus (SeV) and RIG-I stimulated IFN-β production, and further identified that LMP1 promotes RIG-I degradation, interestingly, the expression level of RIG-I on NPC cell line C666-1, which possesses EBV genome, is significantly lower than EBV negative NPC cells and could not be induced by IFN-α. Here, IFNA1 is linked to nasopharyngeal carcinoma.