PKNOX1 and nervous system disorder: Overexpression of Prep1 causes fatty acid binding protein (FABP)-7 promoter trans-activation in cultured neuroblastoma cells and as, FABP7 function is necessary for neuro- and glio-genesis, particularly for the establishment of the glial fibers and the proper migration of immature neurons to cortical layers, it is possible that Prep1-mediated FABP7 overexpression may contribute to the DS-associated neurological disorders (30).