PPARD and neoplasm: A large body of evidence revealed that ligand activation of PPARβ/δ can prevent tumor promoting inflammation and induce terminal differentiation of cancer cells (Aung et al., 2006; Yang et al., 2010; Peters et al., 2015b), which could reverse sustained cell proliferation and promote sensitivity to growth suppressors (Aung et al., 2006; Peters and Gonzalez, 2009).