HCRT and nervous system disorder: Orexin and orexin receptors are ectopically expressed in many diseases (Perez et al., 2015; Imperatore et al., 2017), especially neurological disorders (Feng et al., 2014; Liguori et al., 2014), suggesting that the orexin/receptor pathway plays critical roles in the pathology and pathogenesis of these illnesses.